Tritium Incorporation
Our company specializes in delivering bespoke tritium radiosynthesis services tailored to the precise needs of our clients. Our proficiency extends to labeling a wide array of compounds, spanning nucleotides, peptides, proteins, antibodies, and carbohydrates. Recent strides in tritium radiosynthesis technology have witnessed remarkable advancements, and our company is adept in harnessing the following methodologies:
Tritium Gas Exchange Using Modern Catalysts
This technique involves effecting the exchange of hydrogen moieties within the target molecule with tritium atoms, facilitated by a catalyst.
Tritiated Water Exchange
Tritiated water exchange presents a facile and efficacious avenue for tritium labeling, notably apt for compounds such as nucleotides and pyrimidines.
Catalytic Reduction with Tritium Gas
Functional groups within the target molecule undergo reduction utilizing tritium gas in conjunction with a catalyst.
Reduction with [3H]Borohydride
This method offers a versatile modality for tritium labeling, particularly suited for compounds necessitating the reduction of carbonyl groups.
Catalytic Dehalogenation with Tritium Gas
This technique entails the substitution of halogen moieties within the target molecule with tritium atoms under the catalytic influence.
Catalytic Photoredox Tritiation
Utilizing a photocatalyst, this approach mediates the transfer of tritium atoms to the target molecule.
High Specific Activity Methylation Using [Methyl-3H]Nosylate
Involving the methylation of functional groups within the target molecule employing tritiated nosylate.
Covalent Tritium Labeling of Macromolecules Using [3H]NSP
This method entails the covalent attachment of tritium-labeled moieties to macromolecules, such as proteins and nucleic acids.
Product Purification
Through advancements in semi-preparative and preparative HPLC, TLC, paper chromatography, low-pressure columns, and wet techniques, our company continues to spearhead the purification of tritium radiosynthesis products. Offering a comprehensive array of purification technologies, our company empowers researchers and pharmaceutical entities to confidently advance their research objectives in tritium radiosynthesis.
Analytical Support
Our company extends comprehensive analytical support for tritium compounds, ensuring the integrity and quality of synthetic products.
- Our cutting-edge analytical techniques, including LC-MS/MS, HPLC or UPLC with UV and flow-type radioactivity detectors, NMR (including 3H-NMR), gas chromatography, and supplementary methods such as FT-IR, DSC, TGA, and KF analysis, enable precise characterization of tritium compounds, facilitating structural confirmation and determination of tritium binding efficiency.
- Moreover, our company ensures compliance with regulatory standards, including GLP analysis where requisite, to meet the stringent mandates of the life sciences industry.
