Inflammation and Pain Models
Inflammation and Pain Models
Services
Online Inquiry
Verification code

Inflammation and Pain Models

Inflammation and Pain Models

  • Inflammation and Pain Models
  • Neuropathic Pain Models

Inflammation and pain are complex physiological responses involving intricate molecular pathways. Animal models play a crucial role in elucidating these mechanisms and evaluating potential therapeutics. Our company is a renowned name in the material sciences industry, providing high-quality services in providing inflammation and pain model services.

Our Inflammation and Pain Models

Our company's in vivo pharmacology team specializes in establishing and validating various animal models for inflammation and pain diseases including:

Neuropathic Pain Models

Inflammation Models

Neuropathic Pain Models

Neuropathic pain, characterized by nerve damage, presents significant challenges in treatment. Our company offers expertise in neuropathic pain models such as Chronic Constriction Injury (CCI), Spared Nerve Injury (SNI), and models induced by specific drugs like vincristine, bortizomib, and paclitaxel. These models mimic human neuropathic pain conditions, enabling precise efficacy evaluations of novel therapeutics.

Inflammation Models

  • Inflammation plays a pivotal role in various diseases, including arthritis, colitis, and gout. Our company's services encompass a wide range of inflammation models such as Carrageenan, LPS-induced cytokine release, delayed-type hypersensitivity, NGF-induced pain, and more. These models help in studying drug responses, cytokine profiles, and immune system modulation, crucial for developing anti-inflammatory therapies.
  • In addition to established inflammation models, our company covers specialized models such as Rotorod assays, CLP, diuretic assays, cytokine release models, and arthritis models including adjuvant-induced, collagen-induced, and gout models induced by MSU crystals. These models expand the scope of research, addressing specific disease pathways and therapeutic targets.

Development and Validation of Disease Models

Our company's proficiency lies in developing and validating disease models relevant to inflammation and pain. These models mimic human conditions, allowing researchers to study disease mechanisms, test hypotheses, and assess therapeutic interventions in a controlled environment.

Maximum Tolerated Dose Studies

Determining the maximum tolerated dose (MTD) of a drug is crucial for establishing safe dosing regimens in clinical settings. Our company conducts MTD studies meticulously, evaluating dose-response relationships, monitoring adverse effects, and defining safe dosage ranges.

Dose Range Finding Studies

Optimizing drug dosages for desired therapeutic effects while minimizing side effects is a delicate balance. Dose range finding studies conducted by our company help identify effective dose ranges, evaluate pharmacokinetic parameters, and assess drug exposure levels.

Efficacy Studies

Evaluating the efficacy of potential therapeutics is paramount in drug development. Our company designs and executes efficacy studies using validated disease models, measuring relevant endpoints such as pain thresholds, inflammation markers, and disease progression parameters.

Analytical Platforms

Our company utilizes state-of-the-art analytical platforms to assess drug exposure in:

  • blood and tissues
  • specific biomarkers
  • gene/protein analysis
  • FACS analysis
  • Histology
  • biochemistry
  • IHC
  • blood sample analysis

Our company's expertise in inflammation and pain models, coupled with advanced analytical capabilities and integrated services, positions it as a leader in preclinical pharmacology research. Contact us to learn more about how we can support your scientific endeavors and help you achieve your goals.

Trust Us for Your Pharmaceutical Development Needs.

Our company offers a comprehensive range of inflammation and pain model services to support a wide range of research and development efforts in the pharmaceutical, biotechnology, materials science and chemical industries.

Please kindly note that our products and services are for research use only.