Carbon-14 Radiosynthesis
The production of Carbon-14 labeled compounds typically includes synthesis and HPLC purification, as well as any final steps to convert the product into the desired final form, including but not limited to crystallization, salt formation or removal, dilute with label free material, dissolution, freeze-dried. In the realm of Carbon-14 radiosynthesis, our company boasts an impressive array of expertise, covering diverse molecule types and synthesis techniques:
Covalent Radiolabelling Techniques with 14C (RadioTag)
Our team excels in covalent radiolabelling techniques with Carbon-14, utilizing RadioTag for labeling various molecule types. This technique enables precise tagging of compounds, ensuring accurate tracking and analysis in research studies.
14C Peptides
Leveraging solution chemistry and cutting-edge auto-synthesizers, we specialize in the synthesis of Carbon-14 labeled peptides. Whether for pharmaceutical research or biochemical studies, our expertise in 14C peptide synthesis facilitates the investigation of peptide metabolism and interactions.
14C Proteins
Our company is at the forefront of Carbon-14 labeling of proteins, offering expertise in synthesizing 14C-labeled proteins, including recombinant proteins produced through fermentation processes. This capability enables researchers to study protein dynamics, folding, and interactions with unparalleled precision.
14C Biomolecules
Our proficiency extends to Carbon-14 labeling of biomolecules via fermentation, adhering to stringent containment protocols. With our specialized techniques, we can label biomolecules such as nucleic acids and carbohydrates, facilitating investigations into biological pathways and cellular processes.
14C Covalent Radiolabelling for ADME Studies
Our company provides rapid and efficient Carbon-14 covalent radiolabelling methods for "tagging" molecules intended for absorption, distribution, metabolism, and excretion (ADME) studies. By accurately tracing the fate of labeled compounds in biological systems, our services support drug development and pharmacokinetic assessments.
Analytical Support
In the realm of Carbon-14 radiosynthesis, analytical chemistry support plays a pivotal role in ensuring the integrity and quality of synthesized compounds. We offer comprehensive analytical chemistry support to validate the purity and identity of synthesized compounds.
- Our state-of-the-art analytical facilities include mass spectrometry (LC-MS/MS), HPLC or UPLC with radio-detection, NMR, GC, FT-IR, DSC, TGA, and Karl Fischer titration.
- We also provide analysis for radiochemical purity, chemical purity, chemical concentration, specific activity, and structural confirmation, ensuring compliance with regulatory standards and meeting the rigorous demands of scientific research.
