Genotoxicity Screening Assays
Our genotoxicity screening assays employ various techniques to detect potential hazards early in the drug development process.
- Micro Ames, Mini Ames, and Ames Tests: These bacterial assays assess the mutagenic potential of compounds, adhering to Good Laboratory Practice (GLP) standards.
- In vitro Micronucleus Assay: Utilizing CHO cells, human lymphocytes, and other cell lines, this assay evaluates chromosomal damage induced by test substances.
- In vitro Chromosome Aberration Assay: Conducted in CHO cells and human lymphocytes, this assay identifies structural chromosomal abnormalities.
- Gene Mutation Assay (Mouse Lymphoma): Evaluates mutations in genes associated with carcinogenesis, providing insights into potential carcinogenicity.
- In vivo Rodent Assays: Including rodent bone marrow micronucleus and chromosome aberration assays, these assays assess genotoxicity in living organisms.
GLP Standard Genotoxicity Assays
Our GLP standard assays are designed to meet regulatory requirements and ensure the reliability and integrity of our data.
- Ames Test: A bacterial assay conducted in accordance with GLP standards to evaluate mutagenic potential.
- In vitro Micronucleus Assay: Utilizing CHO cells, TK 6 cells, and human lymphocytes, this assay detects chromosomal damage induced by test substances.
- Chromosome Aberration Assay: Conducted in CHO cells and human lymphocytes, this assay identifies structural chromosomal abnormalities.
- Gene Mutation Assay (Mouse Lymphoma): Evaluates mutations in genes associated with carcinogenesis.
- In vivo Rodent Bone Marrow Micronucleus Assay: Conducted independently or integrated into general toxicology studies in rodents, this assay provides valuable insights into compound-induced genotoxicity.
Other Services
In addition to our core genetic toxicology services, our company offers supplementary services to support our clients' diverse needs.
- Metabolic Activation Studies: Evaluate the role of metabolic pathways in compound genotoxicity.
- Regulatory Support: Assistance in navigating genetic toxicology regulations and guidelines.
- Expert Consultation: Tailored consultancy services to assist clients in study design, interpretation, and regulatory compliance.
