Analytical and Purification Services

Analytical Services

With a rich legacy of over two decades in the field, we offer a suite of cutting-edge analytical techniques and state-of-the-art instrumentation to deliver precise, reliable, and actionable insights into the composition, structure, and properties of chemical compounds. Our analytical services span a wide range of methodologies, enabling researchers to unravel the complexities of molecular structures, identify impurities, assess quality, and drive innovation in drug discovery and development.

Mass Spectrometry

• LC-MS (Liquid Chromatography-Mass Spectrometry): Our LC-MS capabilities enable high-throughput analysis and quantification of compounds in complex matrices, providing valuable insights into molecular composition and structure.
• Q-TOF Mass Spectrometry: With high-resolution Q-TOF mass spectrometers, we achieve superior accuracy and sensitivity in mass determination, facilitating precise molecular characterization and identification.
• Low-Resolution Mass Spectrometry (LRMS): LRMS offers rapid screening and qualitative analysis of compounds, providing valuable information for initial characterization and assessment.

Nuclear Magnetic Resonance (NMR) Spectroscopy

• 1H NMR Analysis: Our 1H NMR capabilities enable detailed analysis of hydrogen atoms in molecules, offering insights into molecular structure and conformation.
• 13C NMR Analysis: With 13C NMR spectroscopy, we elucidate the carbon atom environment within molecules, aiding in structural characterization and identification.
• Multidimensional NMR Experiments: Leveraging advanced multidimensional NMR techniques, we unravel complex molecular structures and interactions with unparalleled precision.

Chromatography

• UPLC-MS (Ultra-Performance Liquid Chromatography-Mass Spectrometry): Our UPLC-MS systems offer high-resolution chromatographic separation coupled with mass spectrometric detection, enabling accurate identification and quantification of compounds in complex mixtures.
• Preparative HPLC (High-Performance Liquid Chromatography): With preparative HPLC capabilities, we purify compounds at scale, facilitating the isolation of target molecules with high purity and yield.
• Reverse-Phase Liquid Chromatography: Our reverse-phase LC systems excel in separating compounds based on hydrophobicity, enabling efficient purification and analysis of a wide range of molecules.

Other Analytical Techniques

• IR Spectroscopy (Infrared Spectroscopy): IR spectroscopy offers valuable insights into molecular structure and composition, aiding in the identification of functional groups and chemical bonds.
• Polarimetry: Utilizing polarimeters, we measure optical rotation to determine the chirality and purity of chiral compounds, ensuring compliance with regulatory standards.
• Karl Fischer Titration: Our Karl Fischer titration systems enable accurate determination of water content in samples, crucial for assessing stability and quality in pharmaceutical formulations.

Purification Capabilities

Our purification services cover a wide range of applications, from routine separations to complex purification challenges, ensuring the highest levels of purity and quality in every endeavor.

• Preparative HPLC (High-Performance Liquid Chromatography): Our Prep-HPLC systems are equipped with advanced detection modules and columns, enabling precise separation and purification of compounds at various scales. From milligram to tens of kilogram scales, we deliver high-purity compounds with exceptional efficiency and yield.
• Preparative SFC (Supercritical Fluid Chromatography): Leveraging the unique properties of supercritical fluids, our Prep-SFC systems excel in separating complex mixtures, particularly highly lipophilic compounds and enantiomeric mixtures. With superior selectivity and efficiency, we achieve unparalleled purity in compound purification.
• MS-Triggered Prep-HPLC: Our innovative approach integrates mass spectrometry into purification workflows, enabling real-time monitoring and optimization of chromatographic separations. By coupling mass spectrometric detection with preparative HPLC, we enhance efficiency and accuracy in compound purification, expediting the path from discovery to development.
• High-Throughput Purification: At our company, we offer high-throughput purification services tailored for library compounds, including DNA-encoded libraries. Our automated purification platforms and high-throughput LCMS systems enable rapid screening and purification of compound libraries, facilitating efficient drug discovery and development processes.
• Counter-Current Chromatography (CCC): Our company utilizes CCC for the purification of natural products and complex mixtures, offering high-purity fractions with minimal sample loss.
• Flash Chromatography: Our Flash chromatography systems enable rapid and cost-effective purification of compounds, ideal for routine separations and scale-up processes.