Small Molecule Bioanalysis Services

Traditional Small Molecules
Nucleotides/Nucleosides and Oligonucleotides
Peptides and Oligosaccharides
Lipids and Non-Lipinski Molecules
Others

Our company stands at the forefront of small molecule bioanalysis services, leveraging over 20 years of expertise in the life sciences industry. Our commitment to excellence and innovation has positioned us as a leading provider in the field, catering to the diverse needs of drug discovery and development programs.

Types of Small Molecules

Our company's small molecule bioanalysis services encompass a broad spectrum of analytes. These will include some of the more common ones such as:

Traditional Small Molecules

Nucleotides/Nucleosides and Oligonucleotides

Peptides and Oligosaccharides

Lipids and Non-Lipinski Molecules

Others

Traditional Small Molecules

From initial discovery to clinical development, our expertise spans a wide array of small molecule drugs, including those conforming to the Lipinski rule of five. By employing state-of-the-art analytical techniques, we ensure accurate quantitation and characterization of these critical compounds.

Nucleotides/Nucleosides and Oligonucleotides

Our company is at the forefront of bioanalytical support for nucleotides, nucleosides, and oligonucleotides, offering specialized expertise in their analysis. Whether it's siRNA, antisense oligonucleotides, or peptide nucleic acids, our team possesses the knowledge and tools necessary to elucidate their pharmacokinetic and pharmacodynamic profiles with precision.

Peptides and Oligosaccharides

Our company boasts proficiency in the analysis of peptides, ranging from linear to cyclic, branched, and conjugated forms. Additionally, our capabilities extend to oligosaccharides, enabling the comprehensive characterization of these complex molecules. With a focus on robust method development, we ensure accurate quantitation of peptides and oligosaccharides in diverse biological matrices.

Lipids and Non-Lipinski Molecules

Beyond traditional small molecules, our company caters to the analysis of lipids and other non-Lipinski-rule-of-five molecules. Lipid-based therapeutics, including lipid nanoparticles (LNPs), pose unique challenges in bioanalysis, which our team adeptly navigates. Whether it's glycosphingolipids, ceramides, sphingolipids, or gangliosides, we employ advanced analytical techniques to characterize lipid-based compounds with unparalleled accuracy and sensitivity.

Others

In addition to the aforementioned classes of molecules, our company offers expertise in a myriad of other analytes relevant to drug discovery and development. From amino acids and steroids to polypeptides, toxins, and metabolites, our analytical capabilities span a diverse range of compounds. By leveraging our comprehensive analytical toolbox, we empower our clients with the insights needed to advance their drug R&D programs efficiently and effectively.

Analytical Approaches

With a focus on advanced analytical approaches, we offer tailored solutions to meet the diverse needs of drug discovery and development programs.

Liquid Chromatography Mass Spectrometry (LC-MS/MS)

At our company, we leverage LC-MS/MS across various stages of drug R&D, from discovery to clinical development. Our state-of-the-art LC-MS/MS platforms, coupled with advanced sample preparation techniques, ensure robust and accurate analysis of small molecules, metabolites, and biomarkers in biological matrices.

Hydrophilic Interaction Chromatography (HILIC)

At our company, we leverage HILIC in conjunction with LC-MS/MS to analyze challenging analytes such as peptides, nucleotides, and carbohydrates. This powerful combination of techniques enables the accurate characterization and quantitation of a wide range of small molecules, expanding the scope of our bioanalytical capabilities.

Solid Phase Extraction (SPE) and Liquid-Liquid Extraction (LLE)

SPE and LLE are among the key methodologies utilized by our scientists. By employing these techniques, we enhance the sensitivity and accuracy of our analytical assays, facilitating robust data generation across various biological matrices.

Size Exclusion Chromatography (SEC)

At our company, we leverage SEC in combination with other chromatographic techniques to analyze complex samples containing small molecules, peptides, and nanoparticles. This enables us to characterize the composition and structure of diverse analytes with precision, contributing to a comprehensive understanding of their pharmacokinetic and pharmacodynamic properties.

Ligand Binding Assays

In addition to LC-MS/MS, our company harnesses the power of ligand binding assays to complement its bioanalytical capabilities. These assays, including enzyme-linked immunosorbent assays (ELISA) and radioimmunoassays (RIA), provide valuable insights into target engagement and biomarker quantitation. By integrating ligand binding assays with LC-MS/MS, we offer a comprehensive approach to small molecule bioanalysis, enabling thorough characterization and quantitation of analytes across diverse biological samples.

Our company's small molecule bioanalysis services are underpinned by advanced technological capabilities, empowering our clients with the insights needed to drive innovation in drug discovery and development. Contact us today to discuss your needs.

Trust Us for Your Bioanalysis Needs.

Our company offers a comprehensive range of small molecule bioanalysis services to support a wide range of research and development efforts in the pharmaceutical, biotechnology, materials science and chemical industries.

Please kindly note that our products and services are for research use only.