Comprehensive Evaluation
Safety pharmacology studies serve as a cornerstone in any Investigational New Drug (IND)-enabling program. Our company's team of experts conducts thorough evaluations to identify and mitigate risks associated with drug candidates. Our services encompass a comprehensive assessment of key physiological systems, including the cardiovascular, respiratory, central nervous, renal/urinary, and gastrointestinal systems.
Early-Stage Support
Recognizing the importance of early intervention, our company extends its safety pharmacology services to the discovery and lead optimization phases of drug development. By evaluating programs at these early stages, we aim to expedite the preclinical phase and minimize potential setbacks in later stages of development.
Core Battery Testing
Our safety pharmacologists integrate a core battery of tests essential for assessing the safety profile of small molecule drugs. This includes the Functional Observation Battery (FOB) study for the central nervous system, radiotelemetry models for cardiovascular assessment, and plethysmograph models for respiratory function evaluation. Additionally, we conduct hERG assays to evaluate cardiac ion channels, crucial for predicting cardiovascular risk.
Supplementary Studies
In addition to core battery testing, our company offers supplemental safety pharmacology studies to provide a comprehensive evaluation of drug candidates. These studies focus on assessing the impact on the renal/urinary and gastrointestinal systems, ensuring a holistic understanding of the safety profile.
Pharmacology Efficacy Studies
Beyond safety assessment, our company specializes in pharmacology efficacy studies across multiple animal species. Our established models cover a wide spectrum of diseases and conditions, including hemostasis, leukocytopenia, neutropenia, anemia, wounding/healing, thrombosis, cough, and allergic conjunctivitis. We also offer customized disease models tailored to specific research needs, catering to both rodent and non-rodent species.
