Cardiovascular and Metabolic Models

Type 1 and Type 2 Diabetes Models
Obesity and Hyperlipidemia Models
Hypertension Models
Cardiovascular Damage Models

In the dynamic landscape of biomedical research, cardiovascular and metabolic diseases stand as formidable challenges affecting global health. Understanding the intricate mechanisms underlying these diseases and developing effective therapeutic interventions requires sophisticated experimental models that mirror human pathophysiology. Our company has leveraged its expertise to excel in providing cutting-edge services for cardiovascular and metabolic disease modeling.

Our Cardiovascular and Metabolic Models

Our company's focus on in vivo pharmacology encompasses a wide array of models that mimic human disease conditions, aiding researchers in unraveling complex disease pathways. Our cardiovascular and metabolic models include:

Metabolic Models

Cardiovascular Models

Metabolic Models

Our company's portfolio of metabolic models encompasses a diverse range of conditions including:

Type 1 and Type 2 Diabetes Models

Our company offers robust models for type 1 diabetes (T1D) induced by streptozotocin (STZ), allowing researchers to study autoimmune destruction of pancreatic β-cells and insulin deficiency.
Additionally, models combining diet-induced obesity with STZ administration mimic aspects of type 2 diabetes (T2D), providing insights into insulin resistance and metabolic dysfunction.

Obesity and Hyperlipidemia Models

Our company provides various diet-induced obesity models (e.g., HFD, HSD) and genetically modified models (gDIO, eDIO) to study obesity-related metabolic disturbances such as adipose tissue inflammation, insulin resistance, and dyslipidemia.
Furthermore, specialized models targeting hyperlipidemia, including transgenic models like ApoA1, offer platforms for investigating lipid metabolism and cardiovascular risk factors.

Cardiovascular Models

Our company's in vivo pharmacology team specializes in developing and validating a wide range of cardiovascular disease models that closely mimic human pathophysiology including:

Hypertension Models

The company offers robust models for hypertension, including the widely used Spontaneously Hypertensive Rat (SHR) model. These models enable researchers to investigate mechanisms underlying hypertension development, vascular dysfunction, and potential therapeutic interventions targeting blood pressure regulation.

Cardiovascular Damage Models

In addition to hypertension, our company provides models for studying cardiovascular damage and related conditions such as stroke, heart failure, and myocardial infarction. These models allow researchers to explore cardiac remodeling, ischemic injury mechanisms, and the effects of novel interventions on heart function and tissue repair.

Comprehensive Analytical Techniques

Our company's in vivo pharmacology team employs a spectrum of analytical techniques to assess disease progression and therapeutic outcomes. From enzyme assays like DPP4 activity assessment to sophisticated analyses such as cytokine profiling (IHC, ELISA, WB) and gene expression studies (PCR/qPCR), our services offer a holistic view of disease states.

Specialized Measurements

The company provides detailed measurements crucial for metabolic and cardiovascular research, including urine glucose levels, liver lipid profiles, adipocyte size, and aorta staining (Oil-Red-O). These measurements not only quantify disease markers but also elucidate underlying physiological changes in targeted organs.

Disease Biomarkers

Our company's expertise extends to biomarker analysis, encompassing gene and protein expression profiling, cytokine levels, and metabolic parameters like HbA1C, free fatty acids, and ketones. These biomarkers serve as crucial indicators of disease severity and treatment efficacy in preclinical studies.

Customized Models and Support

Apart from standard models, our company offers customization options for mutant models and genetically modified models upon request. This flexibility allows researchers to tailor experimental conditions to specific research questions, enhancing the relevance and translatability of preclinical findings.

Our company's extensive experience in cardiovascular and metabolic disease modeling, coupled with a comprehensive suite of analytical services, positions it as a leading partner in advancing biomedical research and therapeutic development. Contact us to learn more about how we can support your scientific endeavors and help you achieve your goals.

Trust Us for Your Pharmaceutical Development Needs.

Our company offers a comprehensive range of cardiovascular and metabolic model services to support a wide range of research and development efforts in the pharmaceutical, biotechnology, materials science and chemical industries.

Please kindly note that our products and services are for research use only.