CNS/PNS Models

Seizure disorders
Parkinson's disease
Depression, anxiety, and schizophrenia
LPS-induced neuroinflammation
Migraine
Alzheimer's disease and memory impairment
Experimental autoimmune encephalomyelitis (EAE) model for multiple sclerosis
Other neurodegenerative diseases

Central Nervous System (CNS) and Peripheral Nervous System (PNS) diseases encompass a broad spectrum of neurological disorders that affect millions of individuals worldwide. These conditions can range from degenerative disorders like Alzheimer's and Parkinson's diseases to psychiatric disorders such as depression and anxiety, as well as neurological inflammatory conditions like multiple sclerosis (MS) and epilepsy. Our company stands as a premier provider of CNS/PNS disease modeling services, offering expertise, advanced technologies, and a commitment to scientific excellence.

Our CNS/PNS Models

Our company specializes in developing and validating animal models that closely mimic human CNS/PNS diseases. Our expertise covers a wide range of neurological disorders, including but not limited to:

Seizure disorders
Parkinson's disease
Depression, anxiety, and schizophrenia
LPS-induced neuroinflammation

Migraine
Alzheimer's disease and memory impairment
Experimental autoimmune encephalomyelitis (EAE) model for multiple sclerosis
Other neurodegenerative diseases

Our company offers a range of services tailored to meet the specific needs of pharmacological research in CNS/PNS diseases.

Disease Model Development and Validation

Our team excels in establishing and validating disease models, ensuring their relevance and reliability in mimicking human pathophysiology. This includes:

Development of novel animal models based on scientific literature and client requirements.
Rigorous validation protocols to confirm disease phenotypes and treatment responses.
Optimization of experimental procedures for consistency and reproducibility.

Pharmacological Profiling and Efficacy Studies

We conduct in-depth pharmacological profiling to assess drug effects on disease models, including:

Maximum tolerated dose studies to determine safe dosage ranges.
Dose range finding to identify effective treatment concentrations.
Efficacy studies to evaluate treatment outcomes and therapeutic potentials.

Analytical Platforms and Techniques

Our company utilizes state-of-the-art analytical platforms and techniques to support pharmacological research:

Measurement of drug exposure in blood and tissues to determine pharmacokinetic profiles.
Analysis of specific biomarkers in blood and tissues to monitor disease progression and treatment responses.
Gene and protein analysis platforms for mechanistic studies and target identification.
Flow cytometry (FACS) analysis for cellular characterization in immune-related diseases.
Histology, biochemistry, and immunohistochemistry (IHC) for tissue analysis and visualization.
Blood sample analysis for comprehensive biochemistry and hematology assessments.
Analysis of body fluids, urine, and feces for drug metabolism and excretion studies.

Other Considerations

Apart from our core services, our company emphasizes collaboration and integration across scientific disciplines. Our internal teams, including PK/Bioanalytical, ex vivo pharmacology, and in vitro biology teams, work seamlessly to provide integrated services, ensuring a holistic approach to pharmacological research.

Our company stands as a premier provider of CNS/PNS disease modeling services, offering expertise, advanced technologies, and a commitment to scientific excellence. Contact us to learn more about how we can support your scientific endeavors and help you achieve your goals.

Trust Us for Your Pharmaceutical Development Needs.

Our company offers a comprehensive range of CNS/PNS model services to support a wide range of research and development efforts in the pharmaceutical, biotechnology, materials science and chemical industries.

Please kindly note that our products and services are for research use only.